| Wed 06-Oct-2021 |
|---|
| 01:00 | Virton | 4‑2 | Union Titus Petange | |
| 01:00 | Waldhof Mannheim | 2‑1 | Türkspor Mannheim | |
| 01:00 | Wolfsburg | 4‑1 | Hamburger | |
| Tue 05-Oct-2021 |
|---|
| 01:00 | Dobrudzha | 0‑2 | Cherno More Varna | |
| 01:00 | Siegburger SV | 2‑3 | Bonner SC | |
| 01:00 | Vohwinkel | 2‑1 | TVD Velbert | |
| Sun 03-Oct-2021 |
|---|
| 01:00 | Rodos | 2‑2 | Olympiakos Volos | |
| Sun 26-Sep-2021 |
|---|
| 19:45 | Comercial PI | 4‑0 | Timon | |
| 19:00 | Bonsucesso | 0‑0 | Barra Mansa | |
| 11:00 | Firhouse | 3‑3 | Cherry Orchard | |
| 11:00 | Kilnamanagh | 3‑3 | Liffeys Wanderers | |
| Thu 23-Sep-2021 |
|---|
| 14:00 | CS Chebba | 2‑2 | Etoile DU Sahel | |
| Wed 22-Sep-2021 |
|---|
| 16:00 | Rejiche | 2‑0 | CS Hammam-Lif | |
| 01:00 | AD Parla | 2‑1 | Illescas | |
| Thu 16-Sep-2021 |
|---|
| 01:00 | Amern | 1‑0 | Fortuna Dilkrath | |
