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| Mon 01-Mar-2021 |
|---|
| 14:00 | Spartak Nalchik | 1‑0 | Salyut-Belgorod | |
| 10:00 | Essentuki | 1‑3 | Mashuk-KMV | |
| Sun 28-Feb-2021 |
|---|
| 20:00 | Portuguesa FC | 1‑0 | UCV | |
| 11:30 | Kuban Kholding | 2‑2 | Novosibirsk | |
| 10:00 | FK Suduva | 1‑0 | Nevežis | |
| Sat 27-Feb-2021 |
|---|
| 20:00 | Fundación Lara Deportiva | 0‑2 | UCV | |
| 14:00 | Mladost Ždralovi | 2‑1 | Zagorec | |
| 10:30 | FK Sokol Saratov | 1‑2 | Kuban Krasnodar | |
| 10:00 | Nafta | 4‑1 | Beltinci | |
| Fri 26-Feb-2021 |
|---|
| 23:30 | Deportivo Lara | 1‑0 | Portuguesa FC | |
| 11:30 | Extremadura | 2‑2 | Salamanca UDS | |
| 10:00 | Essentuki | 4‑2 | Tuapse | |
| 10:00 | Progresul Spartac | 5‑1 | Alexandria | |
| Thu 25-Feb-2021 |
|---|
| 20:00 | Puerto Cabello | 1‑2 | CD Hermanos Colmenarez | |
| 14:00 | Essentuki | 1‑4 | Salyut-Belgorod | |
