| Thu 18-Feb-2021 |
|---|
| 22:00 | Treze | 1‑3 | America-RN | |
| 15:30 | Locomotive Tbilisi | 1‑4 | Linense | |
| 11:00 | Teteks | 4‑0 | Bregalnica Stip | |
| Wed 17-Feb-2021 |
|---|
| 10:00 | Pandurii TG JIU | 1‑1 | Viitorul Dae?ti | |
| 06:30 | Zenit Izhevsk | 1‑2 | Zvezda Perm | |
| Tue 16-Feb-2021 |
|---|
| 19:00 | Campinense | 5‑0 | Potiguar Mossoró | |
| 13:00 | Dunav Ruse | 4‑1 | Etar VT II | |
| 10:30 | Spartak Nalchik | 2‑5 | Legion Dynamo | |
| 06:30 | Zenit Izhevsk | 3‑0 | Krylya Sovetov II | |
| Mon 15-Feb-2021 |
|---|
| 08:30 | Krylya Sovetov II | 0‑2 | Zvezda Perm | |
| 01:30 | Barcelona SC | 1‑1 | 9 de Octubre | |
| Sun 14-Feb-2021 |
|---|
| 11:00 | Kuban Kholding | 1‑0 | Kaluga | |
| Sat 13-Feb-2021 |
|---|
| 18:30 | Treze | 1‑2 | Globo | |
| 17:30 | Wikielec | 2‑1 | Huragan Morag | |
| 14:00 | FK Panevezys | 1‑1 | FK Siauliai | |
