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| Sun 14-Nov-2021 |
|---|
| 14:00 | Cheadle Town Women | 1‑2 | Bradford W | |
| 14:00 | Crawley Women | 3‑2 | London Bees | |
| 14:00 | Derby W | 2‑3 | Stourbridge W | |
| 14:00 | Farsley Celtic W | 2‑0 | Mossley Hill | |
| 14:00 | FC United W | 0‑1 | Brighouse Town Women | |
| 14:00 | Liverpool Feds Women | 2‑0 | Fleetwood Women | |
| 14:00 | Long Eaton United W | 4‑0 | Peterborough W | |
| 14:00 | Millwall Lionesses | 0‑2 | AFC Wimbledon Women | |
| 14:00 | New Milton Town W | 0‑4 | Bridgwater United | |
| 14:00 | Newcastle Women | 5‑1 | Harrogate Town W | |
| 14:00 | Nott'm Forest Women| | 4‑0 | Lichfield City W | |
| 14:00 | Portsmouth W | 13‑0 | Dorking Wanderers W | |
| 14:00 | Sporting Khalsa W | 1‑7 | Wolverhampton Women | |
| 14:00 | Stoneham | 0‑6 | Eastleigh Community | |
| 14:00 | Sutton Utd W | 0‑6 | Ashford Town W | |
