The following are the top scorers in the Ghana Premier League during the 2020-2021 season
- Joseph Esso (Dreams FC) - 10
- Diawisie Taylor (Karela) - 8
- Kwame Peprah (King Faisal Babes) - 8
- Hans Kwofie (Legon Cities) - 8
- Daniel Lomotey (WAFA) - 8
- Mohammed Yahaya (Aduana Stars) - 7
- Kwame Boateng (Karela) - 7
- Yaw Annor (Ashanti Gold SC) - 6
- Moro Salifu (Bechem United) - 6
- Kwame Opoku (Asante Kotoko) - 6
- Victor Aidoo (Hearts of Oak) - 6
- Agyenim Mensah (Dreams FC) - 5
- David Sandan Abagna (Ashanti Gold SC) - 5
- Maxwell Quaye (Great Olympics) - 5
- Augustine Boakye (WAFA) - 5
- Kwadwo Obeng (Hearts of Oak) - 4
- Benjamin Tweneboah (Elmina Sharks) - 4
- Paul Agyei (Berekum Chelsea) - 4
- Moro Sumaila (Ebusua Dwarfs) - 4
- Abass Mohammed (Medeama) - 4
