The following are the top scorers in the USL League One during the 2021 season
- Marios Lomis (Greenville Triumph SC) - 4
- Emiliano Terzaghi (Richmond Kickers) - 8
- Greg Hurst (Union Omaha) - 9
- Garrett McLaughlin (Toronto FC II) - 8
- Marco Micaletto (South Georgia Tormenta FC) - 7
- Jake Keegan (Forward Madison FC) - 6
- Juan Galindrez (Chattanooga) - 6
- Shaan Hundal (Fort Lauderdale CF) - 5
- Mitchell Curry (Fort Lauderdale CF) - 5
- Robert Kristo (North Carolina) - 4
- Damian Rivera (New England Revolution II) - 4
- Venton Evans (Fort Lauderdale CF) - 4
- Kazu (North Texas SC) - 3
- Ricardo Ruiz (Chattanooga) - 3
- Josue Espana (Chattanooga) - 3
- Edison Azcona (Fort Lauderdale CF) - 3
- Noel Buck (New England Revolution II) - 3
- Jay Tee Kamara (North Carolina) - 3
- Derek Gebhard (Forward Madison FC) - 3
- Gibran Rayo (North Texas SC) - 3
